Atopic Dermatitis and its Relation to Food Allergy

François Graham; Philippe A. Eigenmann


Curr Opin Allergy Clin Immunol. 2020;20(3):305-310. 

In This Article

Patterns of Clinical Reactivity to Foods in Patients With Atopic Dermatitis

Children with atopic dermatitis present with three types of reactions to foods on OFC: immediate IgE-mediated reactions, delayed exacerbation of atopic dermatitis (thought to be non-IgE mediated),[41] or a mixed presentation.[42] Immediate reactions generally occur within 2 h and display typical characteristics of IgE-mediated food allergic reactions: skin symptoms including urticaria/angioedema, respiratory symptoms, digestive symptoms, cardiovascular or neurologic symptoms.[43] The majority of patients with atopic dermatitis present with cutaneous symptoms. On the other hand, delayed reactions generally occur within 6–48 h after OFC[42] and consist of atopic dermatitis flare-up. Finally, up to 40% of patients present with initial immediate reactions, followed by delayed exacerbation of atopic dermatitis.[1]