Higher Neonatal Vitamin D Levels Tied to Lower Risk of Childhood Asthma

Sarfaroj Khan 

April 22, 2020


  • Higher neonatal 25-hydroxyvitamin D3 (25[OH]D3) concentrations may lower the risk of developing childhood asthma at ages 3-9 years.

Why this matters

  • Findings suggest that prenatal vitamin D concentrations are important for the development of foetal lung and immune system and reduce the risk of asthma later in life.

Study design

  • A case-cohort study included 911 children with asthma (cases) and 1423 children from random sub-cohort using data from the Danish biobank and register databases.

  • The effects of neonatal vitamin D status on the development of asthma between age 3-9 years were evaluated across different quantiles (Q1-Q5).

  • Funding: This study was a part of the D-Tect study funded by the Danish Agency for Science, Technology and Innovation, the Ministry of Science, Higher Education, under the instrument “Strategic Research Projects”.

Key results

  • The median 25(OH)D3 concentration was slightly lower in children with asthma (23 [interquartile range (IQR), 14-35] nmol/L) vs children from the sub-cohort (25 [IQR, 14-40] nmol/L).

  • After adjustment for confounders, the risk of developing asthma between age 3-9 years was lower for children in the fifth quintile vs with those in the first quintile (aHR, 0.55; 95% CI, 0.39-0.77).

  • In analyses stratified by sex and season of birth, the association appeared stronger in boys (aHR, 0.53; 95% CI, 0.34-0.83) than girls (aHR, 0.62; 95% CI, 0.36-1.07); and in those born in August-January (HR, 0.51; 95% CI, 0.33-0.79) than those born in February–July (HR, 0.66; 95% CI, 0.43-0.99).


  • Risk of residual confounding.



Thorsteinsdottir F, Cardoso I, Keller A, Stougaard M, Frederiksen P, Cohen AS, Maslova E, Jacobsen R, Backer V, Heitmann BL. Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study. Nutrients. 2020;12(3). doi: 10.3390/nu12030842. PMID: 32245170.  View abstractView full text (free).

This clinical summary first appeared on Univadis from Medscape.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: