Clinical and Lung Function Outcomes in a Cohort of Children With Severe Asthma

Patricia de Gouveia Belinelo; Aleisha Nielsen; Bernadette Goddard; Lauren Platt; Carla Rebeca Da Silva Sena; Paul D. Robinson; Bruce Whitehead; Jodi Hilton; Tanya Gulliver; Laurence Roddick; Kasey Pearce; Vanessa E. Murphy; Peter G. Gibson; Adam Collison; Joerg Mattes


BMC Pulm Med. 2020;20(66) 

In This Article


Patients with severe asthma (SA) pose a significant challenge to healthcare professionals as it is a complex clinical problem with multiple contributing factors.[1] Uncontrolled SA in children encompasses those who are difficult to treat or have comorbidities, as well as those who are truly refractory to intervention.[2,3] Difficult to treat asthma may occur as a result of poor medication adherence or inhaler technique, adverse environmental conditions (e.g., smoke, allergens, weather), and the child's and family's (lack of) knowledge of and attitudes towards asthma.[4–6] Comorbidities adversely affecting asthma control include obesity, allergic rhinitis, psychosocial factors, and obstructive sleep apnoea.[7] SA has a great impact on the quality of life (QOL) of children.[8] Management of uncontrolled SA may require a personalised treatment approach that involves a multidisciplinary team and is informed by a comprehensive set of clinical assessments. However, data on clinical outcomes employing this model of care in children with uncontrolled severe asthma are sparse.

This report, therefore, aims to retrospectively describe our "real world" experiences and outcomes managing children with severe asthma in the nurse-led severe asthma clinic (SAC) at the John Hunter Children's Hospital, Newcastle, Australia.