Therapeutic Potential of the Gut Microbiota in the Management of Sepsis

Matteo Bassetti; Alessandra Bandera; Andrea Gori


Crit Care. 2020;24(105) 

In This Article

Conclusion and Future Perspectives

Despite the impressive achievement that has been made in knowledge of the microbiome, there is still a huge gap about the microorganisms that reside outside the gut and interactions of bacteria with viruses, archeae, helminths, fungi, and protozoa, which influence each other and in turn regulate the host. In the context of critically ill septic patients, we need large human cohort studies that document microbiota composition, prior to, during and after an episode of sepsis in order to identify protective commensals and microbiota potentially associated with increased susceptibility and worse outcome.

At the same time, new treatment opportunities are gaining space in clinical practice, including the addition of a probiotic, or by tailoring microbiome therapy and selecting specific commensal repletion that could target a specific infectious disease. In this setting, human studies and randomized clinical trials are challenging but still fundamental in order to translate basic research into innovative paradigms.