Is H pylori Infection a Risk Factor for Diabetes Mellitus?

Sarfaroj Khan

April 08, 2020


  • This meta-analysis suggests a positive association between Helicobacter pylori (H pylori) infection and diabetes mellitus.

Why this matters

  • Several studies have investigated the role of H pylori in the pathogenesis of diabetes and its complications, but the results are inconsistent with each other.

Study design

  • Meta-analysis of 41 case-control studies included 9559 participants (4327 cases and 5232 controls) after a search across electronic databases.

  • Funding: None.

Key results

  • A significant positive association was observed between H pylori infection and diabetes (pooled OR, 1.27; 95% CI, 1.11-1.45; I2=86.6%).

  • In the subgroup analysis, H pylori infection was associated with an increased risk for diabetes mellitus (both types) (OR, 1.17; 95% CI, 0.94-1.45; I2=82.5%), type 1 (OR, 1.19; 95% CI, 0.98-1.45; I2=81.6%) and type 2 (OR, 1.43; 95% CI, 1.11-1.85; I2=90.0%) diabetes.

  • In the subgroup analysis by the geographical regions, the Asian population with H pylori infection were at slightly higher risk for diabetes compared with other population.


  • Heterogeneity among studies.

  • Only case-control studies were included.

Mansori K, Moradi Y, Naderpour S, Rashti R, Moghaddam AB, Saed L, Mohammadi H. Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies. BMC Gastroenterol. 2020;20(1):77. doi: 10.1186/s12876-020-01223-0. PMID: 32209055. View abstract. View full text (free).

This clinical summary first appeared on Univadis from Medscape.


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