Week-Old COVID-19 Urology Guidelines Already Outdated

Ingrid Hein

March 24, 2020

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

Recommendations to help clinicians triage surgical procedures during the COVID-19 pandemic, developed quickly by a team of urology experts from around the world and shared last week, are already out of date.

"I would change some things we said a week ago," said David Canes, MD, from Lahey Hospital and Medical Center in Burlington, Massachusetts, and Derry, New Hampshire, who was one of those experts.

"We now know it's not possible to create a cookbook in the face of a rapidly evolving pandemic," he told Medscape Medical News.

"It's heartening that we could do it so fast, but now it's a snapshot in time, a starting point. People have to have conversations locally, in their community, taking into account where they are in relation to a surge of COVID patients, to make good decisions," Canes said.

Long-thought-out guidance can no longer come from societies. "As the pace of information changes so rapidly," Canes said he has changed the way he disseminates information and searches for guidance. "I'm even looking to nontraditional channels, like Twitter."

As the COVID-19 pandemic evolves, informal discussions on social media are helping specialists make decisions. "Threads about various cancers and how people are handling them are helpful," he said.

He described, for example, a thoughtful discussion on the use of androgen-deprivation therapy, a hormone therapy that can block the effects of androgens and can slow the growth of prostate cancer. "This is not a standard-of-care treatment," he said, but now it's being discussed very seriously to treat patients whose care might get delayed.

People have to have conversations locally, in their community, taking into account where they are in relation to a surge of COVID patients, to make good decisions.

A multiple-choice survey was posted on Twitter by Ashish Kamat, MD, MBBS, from the MD Anderson Cancer Center in Houston, asking respondents what they would do for a patient with stage T2 high-grade muscle invasive bladder cancer and normal glomerular filtration during the pandemic.

https://twitter.com/UroDocAsh/status/1241860000823246850

In less than 20 hours, his post received 290 votes in response.

And when Badar Mian, MD, from the Albany Medical Center in New York, asked 23 urologists whether they would recommend radiotherapy (20 fractions) without any chemotherapy, he quickly got two responses: one yes and one no, with explanations.

People are responding to posts quickly. "With the COVID pandemic, we can't wait for consensus guidelines from the American Urology Association or European Association of Urology," Canes said.

One Week Changed Everything

When Canes and his coauthors said last week that prostatectomies should be delayed, they didn't know the extent to which surgery was going to be halted. "When we wrote this statement, most facilities were still allowing elective surgeries or were just on the cusp of shutting down."

Today, if you're in an area where elective surgeries are still allowed or it is early in the crisis, "you might still take a patient with a Gleason 9 and a PSA of 25 and judiciously get the surgery done."

As of March 23, however, surgery in New York City is entirely off the table. "No cancer surgery is happening anymore," Canes reported.

The recommendations suggested using "shared decision-making" to guide radiation therapy choices. "But now, bringing a patient in for daily radiation treatment may not even be feasible, with the effort it takes to clean, the consumption of PPEs, etc," he added.

When the dust settles, there will be a lot of assessment of current decision-making. "We'll see if there are blips in mortality according to decisions being made," Canes said.

The bottom line is that "we're running on a 24-hour news cycle," he pointed out. "It's humbling to see how quickly decision-making changes and how nimble we have to be in making these very difficult decisions that we've never had to make before."

For his own patients, Canes said he is doing consultations by phone or video at this point. "My patients have been very gracious; everyone has a general feeling we're all in this together."

And so far, "I haven't had a situation where I thought the patient wasn't going to survive," he added.

European Association of Urology (EAU) 2020 Congress.

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