Effect of Dexmedetomidine on Duration of Mechanical Ventilation in Septic Patients

A Systematic Review and Meta-Analysis

Peifen Chen; Jihong Jiang; Yunhe Zhang; Guobao Li; Zhihui Qiu; Mitchell M. Levy; Baoji Hu


BMC Pulm Med. 2020;20(42) 

In This Article


The results of our meta-analysis suggest that sedation with DEX in mechanically ventilated adult sepsis or septic shock patients did not improve the duration of mechanical ventilation, but it increased the number of ventilator-free days and reduced 28-day mortality. Because of the limitations of the available studies and sample sizes, a large prospective study is needed to evaluate the influence of DEX on the duration of mechanical ventilation and ventilator-free days in septic patients.