Seasonal Effect on Fatigue, Pain and Dryness in Primary Sjögren's Syndrome

*Number of VAS; ^#in mm; ESSPRI EULAR Sjögren's Syndrome Patient Reported Index

*IS=Immunosuppressive drugs;

*Odds ratios were adjusted on age, immunosuppressive treatment regimens and symptomatic treatments of dryness. ^# Oral and ocular dryness values collected in fall were defined as reference for these analyses.

*Improvements (in mm) of VASs and of the ESSPRI score between seasons, adjusted on age, immuno-suppressive treatment regimens and symptomatic treatments of dryness. ^# Values collected in fall were defined as reference for these analyses.

Authors and Disclosures

Pierre-Marie Duret¹*, Nicolas Meyer², Alain Saraux³, Valérie Devauchelle-Pensec³, Raphaele Seror⁴, Véronique Le-Guern⁵, Claire Larroche⁶, Aleth Perdriger⁷, Jean Sibilia⁸, Vianney Guardiolle², Xavier Mariette⁴ and Jacques-Eric Gottenberg<sup>8,9

1</sup>Department of Rheumatology, Colmar General Hospital, Colmar, France. ²Department of Public Health, GMRC, Strasbourg University Hospital, Strasbourg, France. ³Department of Rheumatology, Brest University Hospital, Brest, France. ⁴Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique - Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, INSERM, Paris, France. ⁵Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France. ⁶Department of internal Medicine, Avicenne Hospital, Bobigny, France. ⁷Department of Rheumatology, Rennes University Hospital, Rennes, France. ⁸Department of Rheumatology, Referral Center for Rare Autoimmune and Systemic Diseases, Strasbourg University Hospital, Strasbourg, France. ⁹CNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence Medalis, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

*Correspondence
pierre-marie.duret@ch-colmar.fr; pierremarie.duret@gmail.com

Authors' contributions
All authors were involved in the drafting of the article or revising it critically for important intellectual content, and all authors approved the final version to be published. All authors were likewise involved in the study conception and design, acquisition of data and analysis and interpretation of data. PMD, NM, VG and JEG had full access to all the data in the study and will take responsibility for the integrity of the data and the accuracy of the data analysis.

Competing interests
The authors declare that they have no competing interests.