Management of Ichthyosis: A Brief Review

Allison L. Limmer, BS, BA; Crystal E. Nwannunu, BS; Ravi R. Patel, MD; Uyen N. Mui, MD; Stephen K. Tyring, MD, PhD


Skin Therapy Letter. 2020;25(1):5-7. 

In This Article

Future Considerations

Topical therapy is necessary in the management of ichthyosis; thus, consideration should be given to the cosmetic appeal and fragrance of treatment creams and ointments. A recent case report found preliminary success utilizing carbocysteine cream in the treatment of ichthyosis.[17] Carbocysteine is a molecule similar to N-acetylcysteine except that it contains a bound sulfhydryl group rather than a free one.[17] As the sulfhydryl group cannot be liberated, this cream lacks the rancid egg smell of N-acetylcysteine cream, a major barrier to treatment compliance.[17] Further research dedicated to such creams, ointments, and even cosmetic products has the potential to improve the quality of life in patients suffering physical discomfort and social stigmata due to their condition. In addition, development of gene therapy has tremendous potential in treating patients with these disorders and should be explored further.