A Primer on Extramammary Paget's Disease for the Urologist

Joon Yau Leong; Paul H. Chung


Transl Androl Urol. 2020;9(1):93-105. 

In This Article

Association With Internal Malignancy

In contrast to Paget's disease of the breast, whereby 100% of patients have an underlying ductal breast carcinoma, the rates of EMPD with an associated malignancy is reported to be 21–29%.[12,45] Controversy exists within the literature regarding this association with concurrent internal malignancies. Chanda demonstrated that topographic locations of EMPD appear to be closely related to the anatomic sites of the underlying malignancy. For example, neoplasms of the male genitourinary tract (e.g., prostate) were associated with penoscrotal EMPD, neoplasms of the gastrointestinal tract (e.g., rectal) were associated with perianal EMPD, and neoplasms of the female genitourinary tract (e.g., squamous cell and adenocarcinoma of the cervix, Bartholin glands) were associated with vulvar EMPD.[12] Therefore, directed screening tests for underlying malignancies based on clinical presentations have been recommended.