Clinical Efficacy of Acellular Dermal Matrix Paste in Treating Diabetic Foot Ulcers

Myungchul Lee, MD, PhD; Dongkeun Jun, MD; Hyungon Choi, MD, PhD; Jeenam Kim, MD, PhD; Donghyeok Shin, MD, PhD

Disclosures

Wounds. 2020;32(2):50-56. 

In This Article

Limitations

The limitations of this study include a lack of histologic support detailing the microscopic aspects of repair. In earlier observations,[10,22,26] micronized ADM appears to support many cellular constituents of tissue regeneration, including fibroblasts, macrophages, plasma cells, adipocytes, and mast cells. The complex provides a loose meshwork of collagen and elastic fibers, serving as a scaffold for vascular ingrowth. Another issue is that of competing ADM formulations (paste vs. sheets), which were not directly compared on an objective basis. However, prior analyses[25] of various ADM preparations and fabrication methods seem to validate this particular indication for ADM paste. Finally, the authors' protocol clearly bears further scrutiny, given the small number of patients assigned to each group.

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