Licensure of a Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus, Haemophilus influenzae Type b Conjugate, and Hepatitis B Vaccine, and Guidance for Use in Infants

Sara E. Oliver MD; Kelly L. Moore, MD


Morbidity and Mortality Weekly Report. 2020;69(5):136-139. 

In This Article

Special Considerations

Before the routine use of Hib vaccines, incidence of H. influenzae meningitis among American Indian/Alaska Native (AI/AN) infants peaked at a younger age (4–6 months) than it did among other U.S. infant populations (6–7 months). Vaccination with a primary series of a Hib vaccine that contains PRP-OMP is preferred for AI/AN infants to provide early protection because these vaccines can provide a protective antibody response after the first dose.[13] Data on antibody response after the first dose of DTaP-IPV-Hib-HepB in AI/AN infants are not currently available; therefore, DTaP-IPV-Hib-HepB does not have a preferential recommendation for AI/AN infants at this time. If data on antibody response after the first dose of DTaP-IPV-Hib-HepB become available, ACIP will re-evaluate the preferential language for the Hib component for AI/AN infants.