Comparison of Ropivacaine Combined With Sufentanil for Epidural Anesthesia and Spinal-epidural Anesthesia in Labor Analgesia

Yanshuang Wang; Mingjun Xu


BMC Anesthesiol. 2020;20(1) 

In This Article


Childbirth is usually the most challenging and painful experience of a mother's life.[1] Fear of childbirth has increased the cesarean delivery rate. Due to the fact that natural vaginal delivery has many advantages compared with cesarean section and promotion of natural vaginal delivery is considered important by the health care systems, labor analgesia has become a key concern for both puerperal and clinical anesthesiologists.[2]

At present, labor analgesia methods include non- pharmacological analgesia and pharmacological analgesia. Non-pharmacological analgesia mainly includes acupuncture, massage, yoga and hydrotherapy and the analgesic effect of which is poor although there is no maternal and fetal injury.[3] For pharmacological analgesia, there are intramuscular analgesics, intravenous analgesics, and spinal analgesia. Among them, intraspinal labor analgesia is the best method for clinical application of analgesia, including continuous epidural analgesia (CEA), combined spinal-epidural anesthesia (CSEA) and continuous spinal anesthesia.[4,5] Epidural analgesia is considered as a widely practiced analgesic technique in clinic worldwide.[6] An ideal labor analgesia method should exhibit good analgesic effect, increase subject satisfaction and comfort, and reduce the incidence of adverse pregnancy outcomes and adverse drug reactions without affecting the progress of labor.[7]

In recent years, with the development of anesthesia technology, combined spinal-epidural anesthesia has increasingly used in labor analgesia because it combines the advantages of epidural anesthesia and spinal anesthesia, including rapid onset, significant analgesic effect, lower drug dosage and fewer side effects.[8,9] However, there are few reports on the specific anesthesia methods and medication regimens of combined spinal-epidural anesthesia, which is not conducive to guiding clinical work. Here, we compared the clinical effects of combined spinal-epidural anesthesia and continuous epidural anesthesia, to provide guidance for clinical work.