Antifungal Therapy: New and Evolving Therapies

Yasmine Nivoix; Marie-Pierre Ledoux; Raoul Herbrecht

Disclosures

Semin Respir Crit Care Med. 2020;41(1):158-174. 

In This Article

Allylamines

Terbinafine interferes with early steps of ergosterol synthesis through the inhibition of squalene epoxidase, resulting in intracellular accumulation of squalene and depletion of ergosterol, leading to its fungicidal activity (Figure 1). Its spectrum comprises dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp.), yeasts (Candida spp., Pityrosporum spp.), some molds, and some dimorphic fungi. Apart from superficial fungal infections, terbinafine has been used as monotherapy or in combination in disseminated Fusarium, Scedosporium, or Phaeohyphomycetes infections.[88] The main adverse events are skin and hepatic disorders.

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