How Well Are We Performing the Initial Assessment of HIV-Positive Patients?

Results From a Multicentre Cohort in Spain

I Suárez-García; B Alejos; E Delgado; M Rivero; JA Pineda; I Jarrin

Disclosures

HIV Medicine. 2020;21(2):128-134. 

In This Article

Methods

We included all patients from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS), which has been described in detail elsewhere,[6,7] from January 2004 to November 2017. CoRIS is a prospective multicentre cohort of adult newly diagnosed HIV-positive treatment-naïve patients, recruited from 45 centres from 13 Autonomous Regions in the Spanish public health care system.

We selected the clinical and analytical assessments that are recommended for all patients at the initial visit by the Spanish AIDS Study Group (GeSIDA) guidelines[2] and for which results are routinely recorded in CoRIS. These include assessments of the following: CD4 count, viral load, hepatitis A, B and C serology, syphilis serology, total cholesterol, plasma creatinine, blood pressure, smoking status, and latent tuberculosis infection. We considered that an examination was performed in the initial evaluation if there was at least one measurement recorded at any time since enrolment in the cohort until the first follow-up visit that took place between 1 and 12 months after enrolment. Patients who did not have a follow-up visit between 1 and 12 months after enrolment were excluded. Some of the centres do not routinely register information on some of the variables and these centres were excluded from analyses of these variables.

Descriptive analysis of patients' characteristics was carried out using frequency tables for categorical variables and median and interquartile range (IQR) for continuous variables. We calculated the percentage of all patients who had each examination performed in the initial evaluation. We used multivariable logistic regression models to identify patients' characteristics independently associated with not having each examination performed in the initial evaluation. All models were adjusted for age, sex, mode of transmission, educational level, place of origin, CD4 count and viral load at cohort enrolment, and year of enrolment.

Wald tests were used to derive P-values. Statistical analyses were performed using STATA software (version 14.0; Stata Corporation, College Station, TX). All patients signed informed consent forms. The study was approved by the Ethics Committee of Instituto de Salud Carlos III (Madrid).

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