Hepatitis B and C Virus Infection and Risk of Haematological Malignancies

Aldo Marrone; Marco Ciotti; Luca Rinaldi; Luigi Elio Adinolfi; Marc Ghany


J Viral Hepat. 2019;27(1):4-12. 

In This Article

Association Between Occult HCV Infection and Haematological Malignancies

Occult HCV infection (OCI) is defined as the presence of HCV-RNA in hepatocytes and in peripheral blood mononuclear cells (PBMC) and absence of detectable HCV-RNA in the serum by standard (routinely) laboratory methods.[55] A few studies reported OCI in blood donors, in some high-risk groups (haemophiliac and haemodialysis patients) and subjects with cryptogenic liver disease.[55–58] A recent study demonstrated OCI in patients who achieved a sustained virological response to IFN-free antiviral therapy for recurrent infection after liver transplantation.[59] No data are actually available in support of OCI in patients with lymphoma.