Gout and Hyperuricaemia in the USA: Prevalence and Trends

Gurkirpal Singh; Bharathi Lingala; Alka Mithal


Rheumatology. 2019;58(12):2177-2180. 

In This Article


We studied adults ≥20 years of age from the NHANES, beginning with the continuous NHANES 2-year survey cycles from 2007–08 to 2015–16. The samples in each cycle were selected using a stratified, multistage, clustered probability sampling design, described in detail elsewhere.[3] A total of 63 776 persons were included in these cycles. Persons with gout were identified from the home interview question 'Has a doctor or other health professional ever told you that you had gout?' Hyperuricaemia was defined as a serum urate level >0.40 mmol/l (6.8 mg/dl) (supersaturation levels at physiological temperatures and pH),[4–6] with alternate definitions of >0.36 mmol/l (6.0 mg/dl)[7] and >0.48 mmol/l (8.0 mg/dl). All statistical analyses were performed with appropriate survey procedures in SAS version 9.4 (SAS Institute, Cary, NC, USA). Survey design variables and weight variables were used to account for the complexity of the NHANES survey design with stratification and clustering. Age-adjusted rates were calculated using 2010 US population numbers (direct standardization).