Opioid-Related Hospitalization and Its Association With Chronic Diseases

Findings From the National Inpatient Sample, 2011-2015

Janani Rajbhandari-Thapa, PhD; Donglan Zhang, PhD; Heather M Padilla, PhD; Sae Rom Chung, MS

Disclosures

Prev Chronic Dis. 2019;16(11):e157 

In This Article

Results

The highest total number of opioid-related hospitalization cases was in 2014 (n = 704,670) (Table 1). From 2011 to 2015, the highest prevalence of opioid-related hospitalization was among patients aged 35–54 years (5-year average, 37%), followed by those aged 18–34 years. The percentages of men and women with opioid-related hospitalizations were approximately equal. The highest prevalence of opioid-related hospitalization was among white patients (5-year average, 72%), and the second-highest was among black patients (5-year average, 15%). The prevalence was higher in urban hospitals (5-year prevalence range, 58%–64%) than in rural hospitals (5-year prevalence range, 36%–42%). The prevalence was also higher among patients who used Medicaid and Medicare than among those who did not. The prevalence of opioid-related hospitalization was highest (94%) among patients with 2 or more comorbid conditions. In 2014 and 2015, as many as 95% of the patients hospitalized for opioid-related causes had 2 or more comorbid conditions.

The prevalence of opioid-related hospitalizations significantly increased among patients with cancer, stroke, obesity, asthma, liver disease, and arthritis across all years (Table 2). The most prevalent chronic disease significantly associated with opioid-related hospitalization was asthma, followed by obesity and liver disease. There was a significant association between opioid-related hospitalization and cancer, stroke, obesity, asthma, and liver disease every year of the study period, with the exception of cancer in 2013 and obesity in 2015. The association between arthritis and opioid-related hospitalizations was significant only in 2014 and 2015, and the association between spinal diseases and opioid-related hospitalizations was significant only in 2012 and 2015.

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