Update: Radiologic-Pathologic Correlation of Hepatocellular Adenoma

Sadhna Dhingra MD, FCAP; Chakradhar Thupili, MD; Steven Chua, MD, PhD; Kaustubh Shirlakar MD; Srinivasa R Prasad, MD; Venkateswar R Surabhi, MD


Appl Radiol. 2019;48(6):21-29. 

In This Article

Abstract and Introduction


Hepatocellular adenoma (HA) is a relatively uncommon benign liver neoplasm that is typically seen in obese women of childbearing age who are on long-term oral contraceptives.[1] It is also reported to occur in men secondary to androgen drug use and in patients with rare metabolic disorders such as glycogen storage disease, maturity onset diabetes of the young and metabolic syndrome.[2–4,5] Accurate identification and characterization of HA is clinically relevant as there is an increased tendency of this distinctive tumor to rupture and cause hemorrhage, to increase in size during pregnancy as well as to undergo malignant transformation.[4] Recent patho-genetic studies have revealed that HA is a heterogeneous entity that may be classified into specific subtypes based on unique molecular signatures, histological features and immunohistochemistry.[1,6–9] Based on characteristic MRI characteristics, specific HA subtypes may be identified non-invasively.[10,11] Radiologists and pathologists have an equally important role to play in the diagnosis and morpho-molecular subtyping of HAs. This review focuses on the radiological and pathological features of HAs and its morphologic subtypes, and in addition dwells on the differential diagnosis of HAs based on imaging characteristics.