The Association of KRAS Mutation With Primary Tumor Location and Survival in Patients Undergoing Resection of Colorectal Cancers and Synchronous Liver Metastases

Niccolo Allievi; Paolo Goffredo; Alan F. Utria; Michele Pisano; Elia Poiasina; Alessandro Lucianetti; Paige Zhou; Imran Hassan


Chin Clin Oncol. 2019;8(5) 

In This Article


In conclusion, the present study suggests a negative prognostic value of m-KRAS and right-sided lesions in a population-based cohort of patients undergoing resection of colorectal cancer and synchronous liver metastases. Our data show that African-American ethnicity and right-sided lesions were associated with m-KRAS. The mutational status of KRAS is likely to be associated with unfavorable tumor biology leading to decreased survival and should be discussed in the context of multi-disciplinary management of patients with colorectal cancer and synchronous liver metastases.