Zika Virus IgM 25 Months After Symptom Onset, Miami-Dade County, Florida, USA

Isabel Griffin; Stacey W. Martin; Marc Fischer; Trudy V. Chambers; Olga L. Kosoy; Cynthia Goldberg; Alyssa Falise; Vanessa Villamil; Olga Ponomareva; Leah D. Gillis; Carina Blackmore; Reynald Jean


Emerging Infectious Diseases. 2019;25(12):2264-2265. 

In This Article


Our findings suggest that approximately three quarters of persons with PCR-confirmed symptomatic Zika disease still have detectable IgM at 25 months after initial illness onset. The prolonged detection of IgM after Zika virus infection is consistent with previous findings for related flaviviruses.[6–10] Our findings are specific to the Centers for Disease Control and Prevention IgM capture ELISA for Zika virus, which targets the premembrane and envelope glycoproteins; other available IgM serologic assays targeting other Zika virus proteins might not produce comparable findings.[3] In addition, these results are only representative of symptomatic Zika cases; whether persons with asymptomatic Zika virus infections exhibit similar Zika virus IgM persistence is unknown. IgM persistence needs to be assessed with other serologic assays for both symptomatic and asymptomatic Zika virus cases to determine the full duration of Zika virus IgM after infection.