Zika Virus IgM 25 Months After Symptom Onset, Miami-Dade County, Florida, USA

Isabel Griffin; Stacey W. Martin; Marc Fischer; Trudy V. Chambers; Olga L. Kosoy; Cynthia Goldberg; Alyssa Falise; Vanessa Villamil; Olga Ponomareva; Leah D. Gillis; Carina Blackmore; Reynald Jean


Emerging Infectious Diseases. 2019;25(12):2264-2265. 

In This Article

Abstract and Introduction


We assessed IgM detection in Zika patients from the 2016 outbreak in Miami-Dade County, Florida, USA. Of those with positive or equivocal IgM after 12–19 months, 87% (26/30) had IgM 6 months later. In a survival analysis, ≈76% had IgM at 25 months. Zika virus IgM persists for years, complicating serologic diagnosis.


Diagnosis of Zika virus infection is accomplished by testing for viral RNA or IgM and neutralizing antibodies.[1] A cohort study of 62 confirmed Zika virus cases from the 2016 outbreak in Miami-Dade County, Florida, USA, demonstrated that Zika virus IgM remains detectable in most (92%) persons 12–19 months after symptom onset.[2] We estimated the proportion of persons with detectable Zika virus IgM up to 25 months after initial illness onset.