What Is the Appropriate Management of Nonfunctioning Pancreatic Neuroendocrine Tumours Disclosed on Screening in Adult Patients With Multiple Endocrine Neoplasia Type 1?

Benjamin G. Challis; Ruth T. Casey; Ashley Grossman; John Newell-Price; Paul Newey; Rajesh V. Thakker


Clin Endocrinol. 2019;91(6):708-715. 

In This Article

What are the Current Best Practice Guidelines for the Management of NF-pNETs?

There is currently no consensus guidance regarding the management of NF-pNETs in patients with MEN1. Figure 1 summarises the current recommendations, largely based on consensus expert opinions, published by the European Neuroendocrine Tumour Society (ENETS),[1] the National Comprehensive Cancer Network (NCCN)[2] and previous guidelines on MEN1.[3] The ENETS and NCCN recommendations essentially relate to non-MEN1 patients.

Figure 1.

A, The European Neuroendocrine Tumour Society (ENETS) recommendations (2016) for the surgical management of NF-pNETs, which advocate surveillance rather than surgery for all incidentally discovered NF-pNETs <2 cm.1 B, The summary of the National Comprehensive Cancer Network (NCCN) guidance for NF-pNETs and recommends surgery for all NF-pNETs measuring >1 cm.2 C, The MEN1 clinical practice guidelines written by a self-assembled group of international experts, which suggests surgical resection for NF-pNETs >1 cm 2