Biomarkers to Predict the Response to Cardiac Resynchronization Therapy

Ward Heggermont; Angelo Auricchio; Marc Vanderheyden


Europace. 2019;21(11):1609-1620. 

In This Article

Biomarkers Related to Oxidative Stress and Apoptosis

Few papers have explored the diagnostic potential of oxidative stress- or apoptosis-related molecules to predict a response to CRT. In a study comprising 51 patients treated with CRT, serum malondialdehyde, catalase, superoxide dismutase, and glutathione peroxidase were all reduced, and correlated with echocardiographic parameters of systolic function.[42] Ceruloplasmin, a metalloprotein that binds copper and has ferroxidase activity, is a marker of oxidative stress and is altered shortly after implantation of CRT, although the clinical usefulness of this finding is still under investigation.[43] On the other hand, annexin A5, a protein related to cellular damage, was monitored in 57 patients with HF that received CRT, at baseline and 1 year of follow-up. No differences between annexin A5 levels at baseline were observed between responders and non-responders, but after 1 year of successful CRT, annexin A5 significantly decreased, and remained unchanged in non-responders.[44]