In its management of adults with type 2 diabetes guidance NICE recommends offering standard-release metformin as the initial drug treatment for adults with type 2 diabetes, and minimising the risk of gastrointestinal side effects by gradually increasing the dose over several weeks. If gastrointestinal side effects occur then a trial of modified-release metformin can be considered. NICE advises that should metformin not be tolerated, or is contraindicated, then for adults with type 2 diabetes initial drug treatment with a dipeptidyl peptidase‑4 (DPP‑4) inhibitor, or pioglitazone, or a sulfonylurea should be considered.
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Cite this: Dr Rob Hicks. Do You Know the Latest on Managing Type 2 Diabetes? - Medscape - Nov 25, 2019.