Orolabial Lymphogranuloma Venereum, Michigan, USA

Sahrish Ilyas; Deborah Richmond; Gerald Burns; Katherine E. Bowden; Kimberly Workowski; Ellen N. Kersh; Pranatharthi H. Chandrasekar

Disclosures

Emerging Infectious Diseases. 2019;25(11):2112-2114. 

In This Article

Conclusions

The prompt diagnosis of LGV infection involving the lip with resultant submandibular adenopathy in this patient was based on a high index of clinical suspicion and specialized laboratory testing. Additional testing at CDC confirmed C. trachomatis serovar L2b.

Rare cases of oral/oropharyngeal LGV have been described (Table).[3–9] For patients who engage in high-risk sexual behavior, with anal–oral contact, LGV is a possible cause of orolabial/oropharyngeal infection. The substantial cervical lymphadenopathy in this patient was reminiscent of inguinal bubo associated with genital LGV, which may serve as a diagnostic clue. Moreover, clinical manifestations in the ongoing epidemic of LGV among MSM show a shift from the classical inguinal form (inguinal adenopathy with penile lesion) to the anorectal form. Our report of orolabial LGV adds to the possibility of gastrointestinal tract infection in this epidemic, perhaps explaining the discrepancy in the ratio of anorectal LGV to inguinal LGV cases.[10]

In the past several years, reports of LGV have been increasing in western Europe and the United States, primarily among MSM.[11] An outbreak of 38 cases of LGV during August 2015–April 2016 encountered at the Wayne State University Physician Group Infectious Diseases Clinic in Detroit was recently reported and occurred among MSM with HIV infection.[12] Among the 38 cases, 21 (55%) were confirmed by the CDC laboratory–developed LGV NAAT[2] on the basis of 19 positive rectal swab specimens and 2 positive swab samples from penile lesions; treatment with doxycycline (100 mg 2×/d for 21 days) was successful for all patients. Although the L2b serovar was correlated with a proctitis outbreak among MSM in Amsterdam in 2000, no cases of LGV at the orolabial site were detected in this outbreak or a 1980s outbreak in San Francisco, California, USA.[13]

The identification of 5' and 3' deletions in ompA indicate a novel subtype of serovar L2b, further highlighting the rarity of this patient's case. Chlamydial MOMP functions as a porin with VD1, VD2, and VD4 at the surface of the chlamydial elementary body directed toward the external environment and host cells. VD4 encodes subspecies-specific neutralizing epitopes.[14,15] It remains unclear how or whether the deletions in CD1, CD4, VD4, and CD5 characterized in this case affect pathogenicity and tissue tropism. Identification of rare clinical manifestations such as this warrant further genetic investigation to provide more information about the molecular mechanisms behind the pathogenesis and transmission of chlamydia.

A widely available Food and Drug Administration–approved molecular test for diagnosis of LGV would be highly useful, especially at the point of care. In its absence, a probable LGV case can be supported by C. trachomatis NAAT positivity of lesion specimens. However, extragenital specimens (e.g., from a lip lesion) are currently not approved by the Food and Drug Administration as a specimen type for commercial C. trachomatis NAAT, which poses a challenge for laboratories because they must perform validations for such specimens for their Clinical Laboratory Improvement Amendments certification. Similar obstacles apply to laboratory-developed LGV-specific testing. As a result, the availability of specific diagnostic testing is scarce. At present, to ensure prompt resolution of symptoms, prevention of complications, and treatment of the sex partner, all suspected cases should be presumptively treated while awaiting diagnostic evaluation.

In summary, this case indicates that LGV infection should be considered for patients, especially MSM, with orolabial lesions and cervical adenopathy. Successful treatment of the patient reported here was based on a C. trachomatis–positive NAAT result, and LGV specialized testing served as a supplement for full investigation of this unusual case.

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