Rachel E. Bridwell, MD; Brandon M. Carius, MPAS, PA-C; Brit Long, MD; Joshua J. Oliver, MD; Gillian Schmitz, MD


Western J Emerg Med. 2019;20(5):822-832. 

In This Article


In the following narrative review, we sought to comprehensively review the recent literature regarding sepsis in pregnancy. While pregnancy has been an exclusion criterion in every major sepsis trial as well as disease-specific trials, we identified all major observational trials, retrospective cohort studies for clinical rule derivation, and their subsequent validation studies.[6–8] We also searched PubMed and Google Scholar from 1966 to October 2018 for English-language articles using a combination of keywords and medical subject headings "pregnancy" and "sepsis" for production of this narrative review, including case reports and series, retrospective and prospective studies, systematic reviews and meta-analyses, narrative reviews, and clinical guidelines. Three authors decided which studies to include for the review by consensus, with 122 resources selected for inclusion, focusing on ED evaluation and management. This review also highlights areas where more research is needed and underscores the protean nature of this complex physiology. As this is a narrative review and not a systematic review and/or meta-analysis, we did not grade the included resources or pool data.