Systemic Doxycycline as an Adjunct to Scaling and Root Planing in Diabetic Patients With Periodontitis

A Systematic Review and Meta-analysis

Kenneth Chou Hung Yap; Shaju Jacob Pulikkotil


BMC Oral Health. 2019;19(209) 

In This Article


To sum up, systemic doxycycline as an adjunct to scaling and root planing does not significantly improve clinical attachment levels for periodontal status as well as reduction of HbA1c levels in treatment of diabetic patients with periodontitis. More randomized controlled trials with a larger population and longer follow-up periods are needed to come up with guidelines to treat diabetic patients with periodontitis in a more effective way than just scaling and root planing. Besides that, more work and planning needs to be done along with information given to reduce the risk of bias and prevent these methodologic shortcomings thus improving the quality of the trials done.