Ketogenic Diet for Schizophrenia: Clinical Implication

Zoltán Sarnyai; Ann-Katrin Kraeuter; Christopher M. Palmer

Disclosures

Curr Opin Psychiatry. 2019;32(5):394-401. 

In This Article

Conclusion

Abnormal glucose and energy metabolism and mitochondrial functioning are emerging as important pathophysiological mechanism in schizophrenia. Therapeutic ketogenic diet shows promise to interfere with these processes resulting in the restoration of normal synaptic communication and alleviation of the devastating psychiatric symptoms. Furthermore, because of the impact of ketogenic diet on systemic metabolism, it is possible that the metabolic features and cardiovascular risk typical of patients with chronic schizophrenia can be addressed by this dietary intervention. However, more research is needed both at preclinical level and in the form of controlled clinical trials before ketogenic diet can take its place in the mainstream of the treatment and management of schizophrenia.

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