On-treatment Biomarkers Can Improve Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer

Richard J. Bownes; Arran K. Turnbull; Carlos Martinez-Perez; David A. Cameron; Andrew H. Sims; Olga Oikonomidou


Breast Cancer Res. 2019;21(73) 

In This Article


We have identified AAGAB as a novel on-treatment biomarker for accurate prediction of pCR and outcome in patients treated with neoadjuvant chemotherapy. A semi-supervised analysis and evaluation of estimations of established molecular signatures also highlight the potential value of on-treatment biomarkers. Combining on-treatment biomarkers with known clinical prognostic factors could further improve the accuracy of response predictions and deserve further study. On-treatment expression changes in the neoadjuvant setting may offer greater possibilities for the identification and creation of more future novel biomarkers.