The Role of Dialysis in the Pathogenesis and Treatment of Dementia

Dearbhla M. Kelly


Nephrol Dial Transplant. 2019;34(7):1080-1083. 

In This Article

Conclusions and Future Research

There is a significant burden of cognitive impairment and dementia in the dialysis population. Although traditionally attributed to vascular disease, mechanisms are likely more complex with background Aβ pathology and metabolic flux induced by dialysis.

Is the renal clearance of Aβ crucial for the preservation of cognitive function and could peripheral Aβ reduction by dialysis serve as a viable anti-amyloid treatment strategy in the future? With or without renal disease, the potential challenge in the application of dialysis to AD patients will be often co-existing and synergistic cerebrovascular disease. Thus, dialysis may be considered as an anti-amyloid treatment strategy although its actual usefulness in patients with AD has still to be elucidated. Further research is needed to better delineate the clearance pathway and demonstrate sustained cognitive improvement.