Immunological Methods for the Diagnosis of Oral Mucosal Diseases

S. Sun; B. Zhong; W. Li; X. Jin; Y. Yao; J. Wang; J. Liu; H. Dan; Q. Chen; X. Zeng


The British Journal of Dermatology. 2019;181(1):23-36. 

In This Article


This review has discussed the diagnostic value of immunological methods for oral mucosal AIBDs, OLP and DLE. Biochemical tests and protein microarrays have huge scope for development. More target antigens and circulating antibodies remain to be identified, and their associations with development of diseases, clinical manifestation, severity of diseases, concomitant diseases and influence on treatment and prognosis also need to be clarified. These advances may provide novel ideas for targeted therapies. In addition, more commercially available ELISA kits and protein microarrays would be beneficial to improve diagnostic accuracy. Currently, there has been some research showing that saliva can offer a diagnostic alternative to serum in ELISAs. A saliva test is noninvasive and convenient in the diagnosis of AIBDs.[139–141] Although detection of the majority of antibodies still has some limitations, a new research field has been provided.

Overall, this review has demonstrated that immunological methods are significant diagnostic tools for AIBDs and auxiliary diagnosis tools for OLP or DLE. We need to further explore the unknown or controversial problems presented in this article, as well as those fields that have already been studied, in order to diagnose diseases and direct clinical treatment.