Our results suggest that ultrasound guidance, HBV infection and the female sex are risk factors of LAST in LPBs and SNBs. For patients infected with HBV or female patients undergoing LPBs and SNBs, combined ultrasound and nerve stimulation guidance should be used to improve the safety. The probable mechanisms are as follows:1) angiogenesis and slower blood flow in deeply located small vessels; and 2) the use of nerve stimulation to avoid injecting LAs into extremely vascularized areas.
BMP-9: Bone Morphogenetic Protein 9; LAs: Local Anesthetics; LAST: Local Anesthetics Systemic Toxicity; LPBs: Lumbar Plexus Blocks; NS: Nerve Stimulator guidance; SNBs: Sciatic Nerve Blocks; US: Ultrasound guidance; VEGF: Vascular Endothelial Growth Factor
To our Families and colleagues.
This project was supported by grants 81870422 and 81670552 from the National Science Foundation of China (NSFC). The funding body plays no role in study design, data collection, or data analyses.
Availability of data and materials
The raw data and materials are available from the corresponding author upon reasonable request.
Ethics approval and consent to participate
This study was approved by the Ethical Committee of the First Affiliated Hospital of Army Medical University. The protocol was registered prospectively with Chinese Clinical Trial Registry (ChiCTR-IOR-16008099) on March 15, 2016. Each participant was informed about the study protocol and the probability of publication of material relating to them in details and complete written informed consents were signed before enrolment in the study.
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BMC Anesthesiol. 2019;19(103) © 2019 BioMed Central, Ltd.