Review Article

Emerging Role of the Gut Microbiome in the Progression of Nonalcoholic Fatty Liver Disease and Potential Therapeutic Implications

Saumya Jayakumar; Rohit Loomba


Aliment Pharmacol Ther. 2019;50(2):144-158. 

In This Article

Microbiota, Microbiome and the Gut

The term "microbiota" refers to a community of microbes in an organism, whereas "microbiome" is used to refer to both the microbiota and the collective genomes and gene products of the microbiota living in or on an organism. The gastrointestinal (GI) tract of humans contains 10 trillion to 100 trillion bacteria, with approximately 15 000-36 000 species.[20,21] Composition of the gut microbiota varies among individuals as the result of multiple intrinsic (eg, age[22,23]) and extrinsic (eg, method of feeding after birth[24,25] and geographic region inhabited[26]) aspects.