Review Article

Emerging Role of the Gut Microbiome in the Progression of Nonalcoholic Fatty Liver Disease and Potential Therapeutic Implications

Saumya Jayakumar; Rohit Loomba


Aliment Pharmacol Ther. 2019;50(2):144-158. 

In This Article

Materials and Methods

A PubMed search was performed for English language articles published between January 1, 2002 and January 31, 2019. Search terms included "cirrhosis" or "insulin resistance" or "liver disease" or "metabolic syndrome" or "NAFLD" or "obesity" or "steatohepatitis" and "microbiome." The search was initially limited to primary publications and those of human subjects; articles reporting animal studies were later retrieved to allow more thorough discussion of pathophysiology. An additional nonsystematic search was performed to gather data on the use of prebiotics, probiotics, symbiotics, synbiotics and antibiotics for NAFLD. A total of 230 articles were retrieved; of these, 60 articles were reviewed. In addition, the bibliographies of these 60 articles were reviewed for additional relevant articles to consider for inclusion.