Safety of Abatacept Compared With Other Biologic and Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis

Data From an Observational Study

Gulsen Ozen; Sofia Pedro; Rebecca Schumacher; Teresa A. Simon; Kaleb Michaud

Disclosures

Arthritis Res Ther. 2019;21(141) 

In This Article

Conclusions

Our study showed that abatacept treatment in patients with RA is associated with low IRs of malignancies, infections, autoimmune diseases and infusion/injection reactions. Our findings suggest the risks of hospitalized infections, malignancies and psoriasis are similar with abatacept and csDMARDs and that the safety profile for abatacept versus other bDMARDs is favourable in terms of hospitalized infections and infusion/injection reactions. Given that patients with RA are already at a higher risk of malignancy and infections than the general population, our findings are likely to be of clinical interest in making therapeutic decisions. However, additional observational research with longer follow-up periods is needed to fully evaluate the comparative safety of abatacept versus other DMARDs in terms of malignancy and mortality.

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3090D553-9492-4563-8681-AD288FA52ACE

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