A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum

David Baltazar, DPT; Carter Haag, BS; Angela S. Gupta, BSc; Angelo V. Marzano, MD; Alex G. Ortega Loayza, MD


Wounds. 2019;31(6):151-157. 

In This Article


Currently, there are numerous treatments for PG, the most common of which are systemic immunosuppressants and immunomodulators. However, their adverse effect profiles and the possible inadequate clinical response can limit their use in some patients with PG, at which point local therapies become crucial in the management of PG. Local treatments commonly target inflammation to treat small or superficial ulcers. They also can be used as adjuvant therapy when systemic medications are providing an insufficient response as monotherapies or are being tapered down. Additional research is needed to determine which patients would most benefit from either local monotherapy or adjuvant systemic and local therapy. It is unclear what kind of patients with PG respond best to topical management, though these topical medications are important therapeutic options at the disposal of clinicians. Understanding their mechanism of action and mode of application are important features when clinicians are considering topical medications for treatment of PG lesions.