The recommended dose of dupilumab in adults and adolescents weighing 60 kg or more is an initial dose of 600 mg (two 300 mg subcutaneous injections) followed by an injection of 300 mg every other week. In adolescents weighing less than 60 kg, the initial dose of 400 mg (two 200 mg injections) should be followed by a dose of 200 mg every other week. The two injections used for the initial dose should be administered at two separate injection sites. Injections may be administered into the thigh or abdomen at least 2 inches away from the navel. The upper arm may be used for injection by a healthcare provider or trained family member. If a dose is missed, it should be administered within 7 days. If the missed dose was more than 7 days ago, the patients should wait until the next dose to resume their injection schedule.
Pediatr Pharm. 2019;25(6) © 2019 University of Virginia