The Use of Antibiotics and Risk of Kidney Stones

Shivam Joshi; David S. Goldfarb


Curr Opin Nephrol Hypertens. 2019;28(4):311-315. 

In This Article


Recent evidence suggests a possible, causal role of antibiotics in the development of kidney stones. A plausible explanation for this finding includes alterations in the microbiome, especially in oxalate-degrading bacteria like O. formigenes, and others, leading to increased urinary oxalate excretion, and ultimately, the development of nephrolithiasis. Other effects on the microbiome are possible but not yet supported. Antibiotics are widely prescribed, with children receiving more antibiotics than other age groups, often for inappropriate reasons. Ample reasons to encourage antibiotic stewardship already exist, but the possible role of antibiotic exposure in contributing to the increasing prevalence of kidney stones in children and adults is one additional rationale.