The Use of Antibiotics and Risk of Kidney Stones

Shivam Joshi; David S. Goldfarb


Curr Opin Nephrol Hypertens. 2019;28(4):311-315. 

In This Article

Therapeutic Implications

The factors that affect the ability of the microbiome to rebound from courses of antibiotics are not known, but could include the diversity of the microbiota constituents, and various host factors including diet. Exposure to antibiotics at a younger age may produce larger changes in the host's metabolism than those that occur at an older age.[34] It may be possible to recolonize people after courses of antibiotics with O. formigenes, and other oxalate degraders and restore the oxalate-degrading capability of their stool.[35] However, the practicality of such a therapy remains unproven, particularly as successful colonization could require the patient's ingestion of sufficient oxalate (with low dietary calcium content).[36] A recent study in rats demonstrated that fecal transplants from one strain into another changed urinary chemistry in the recipients in such a way that theoretically could influence the risk of kidney stones.[37]