Randomized Comparison of Hypochlorous Acid With 5% Sulfamylon Solution as Topical Therapy Following Skin Grafting

Kevin N. Foster, MD, MBA, FACS; K. J. Richey, BSN, RN; J. S. Champagne, MA, RN; M. R. Matthews, MD, FACS

Disclosures

ePlasty. 2019;19(e16) 

In This Article

Results

General demographic data and patient burn characteristics are shown in Table 1. A total of 19 patients participated in the trial. Eleven patients (8 males, 3 females) were in the Vashe Wound Therapy group and 8 (5 males, 3 females) were in the control group. The average age of the patients in the Vashe Wound Therapy group was 43.4 years and 53.6 years for the control group. The mean %TBSA burned was 10% in the Vashe Wound Therapy group and 6.5% in the control group. No significant differences were noted between the 2 groups.

Pain data are also shown in Table 1. Mean baseline pain level was 5.4 in the Vashe Wound Therapy group and 4.5 in the control group. These pain scores were not statistically different.

The location of the study burns is identified in Table 2. Burn location for the 2 groups was fairly equally distributed between upper and lower extremities. Two torso burns were included in the Vashe group.

Average skin graft take on postgrafting day and hospital length of stay (LOS) data are shown in Table 3. There was no difference in graft take between the Vashe and control groups (97.4% and 96.0%, respectively). The LOS was 21.6 days for the Vashe group and 15.6 days for the control group (P = .01).

Cost data are demonstrated in Table 4. The volume of solution used in the Vashe group was more than twice as the volume used in the control group. Even so, the hospital and patient costs were less in the Vashe group than those in the control group. When corrected for volume, Vashe therapy was much less costly than control solution.

There were 3 serious adverse events in the Vashe group and 2 in the control group. None were considered to be related to the study or to study solutions. Nonserious adverse events were also equivalent between the 2 groups. Thus, the safety profiles of the Vashe and control groups were equivalent.

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