Use of Ceftazidime-Avibactam in Infants and Children

Marcia L. Buck, PharmD, FCCP, FPPAG, BCPPS

Disclosures

Pediatr Pharm. 2019;25(5) 

In This Article

Adverse Effects

The most commonly reported adverse reactions with ceftazidime-avibactam in adults enrolled in clinical trials were diarrhea (8%), nausea (7%), and vomiting (5%).[2] In the children from 3 months up to 6 years of age participating in the pharmacokinetic, safety, and tolerability study described earlier, constipation, diarrhea, vomiting, a local infusion site reaction, increased serum transaminases, an elevated triglyceride level, and an increased gamma-glutamyl transferase level were each reported in one patient (3.1% for each reaction).[8] No adverse effects were reported in the patients 6 years of age or older.

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