Use of Ceftazidime-Avibactam in Infants and Children

Marcia L. Buck, PharmD, FCCP, FPPAG, BCPPS


Pediatr Pharm. 2019;25(5) 

In This Article

Contraindications, Warnings, and Precautions

Ceftazidime-avibactam is contraindicated in patients with known severe hypersensitivity to either component or other beta-lactam antibiotics.[2] Severe hypersensitivity reactions, including anaphylaxis and dermatologic reactions, have been reported after ceftazidime-avibactam use. Creatinine clearance should be evaluated daily in any patient with changing renal function or those at risk for worsening function due to illness. Patients with renal impairment are at greater risk for seizures from ceftazidime-avibactam accumulation and require close evaluation and dose adjustment. Clostridium difficile-associated diarrhea (CDAD) has been reported with ceftazidime-avibactam. Patients and their families should be aware of the need to report the development of diarrhea to their healthcare provider.