Anticoagulation in Pediatrics: DOACs on the Horizon

Jasmine Manning, PharmD Candidate 2019; Diane Nykamp, PharmD


US Pharmacist. 2019;44(5):HS8-HS12. 

In This Article

Pharmacists' Role

Pharmacists working with pediatric patients must overcome barriers when selecting appropriate anticoagulation therapy. These include limited dosage formulations, lack of supporting literature for drug use, limited drug-therapy guidelines, and close monitoring during the major phases of growth and development, because pediatric dosing is typically weight-based dosing.

Anticoagulants are a class of drugs associated with a high risk for medication errors and adverse events, making monitoring of dosing and adherence to therapy essential. Institutions have begun implementing pharmacist-led protocols to monitor anticoagulation therapy for patients in adult and pediatric hospitals and outpatient clinics. Pharmacists working with interdisciplinary teams overseeing anticoagulant therapy in pediatric patients can look to the future to assist physicians in selecting therapies based on patient-specific factors, costs, safety and efficacy data, and oral dosage forms, especially with DOACs on the horizon.