Ciprofloxacin and Risk of Hypoglycemia in Non-diabetic Patients

Abiel Berhe; Mulugeta Russom; Fithawit Bahran; Goitom Hagos


J Med Case Reports. 2019;13(142) 

In This Article


This study suggests that ciprofloxacin can cause hypoglycemia even in nondiabetic and previously healthy patients. The seriousness of hypoglycemia and the few deaths reported also underscore the importance of early detection and appropriate management of patients with hypoglycemia. In cases of hyperinsulinemia, use of octreotide has been shown to be effective in abating recurrent hypoglycemic episodes associated with fluoroquinolones.[14]

Taking the risks of hypoglycemia and other previously identified neuropsychiatric adverse effects[25] into consideration, clinicians should avoid the prescription of fluoroquinolones to patients who have other treatment options for acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated urinary tract infections because the risks outweigh the benefits in these patients.[10] Further studies are therefore required to substantiate this safety signal and to identify possible risk factors that expose patients to hypoglycemia.