Updates in the Management of Clostridium Difficile for Adults

Kimberly E. Ng, PharmD, BCPS


US Pharmacist. 2019;44(4):HS9-HS12. 

In This Article


Metronidazole is a nitroimidazole that interacts with DNA to cause a loss of helical DNA structure and strand breakage resulting in inhibition of protein synthesis and cell death in susceptible organisms. Oral metronidazole is 100% bioavailable. However, there is a low concentration of medication at the site of infection due to systemic absorption, which is thought to contribute to reduced efficacy in moderate and severe cases of CDI. Reported adverse effects include headache, nausea, metallic taste, dizziness, and abdominal pain.[6,11]