Intravenous and Oral Tranexamic Acid Are Equivalent at Reducing Blood Loss in Thoracolumbar Spinal Fusion

A Prospective Randomized Trial

Charles C. Yu, MD; Omar Kadri, MD; Allen Kadado, MD; Morenikeji Buraimoh, MD; Jacob Pawloski, BS; Stephen Bartol, MD; Gregory Graziano, MD


Spine. 2019;44(11):755-761. 

In This Article


In conclusion, in the setting of spine thoracolumbar fusions, oral tranexamic acid produced an equivalent reduction in hemoglobin and blood loss compared with its intravenous counterpart. Given the equivalent clinical outcomes, potential cost savings, and the ease of drug administration, oral tranexamic acid is a superior alternative to intravenous tranexamic acid.