Systematic Review With Meta-Analysis

Lactobacillus Rhamnosus GG for Treating Acute Gastroenteritis in Children

A 2019 Update

Hania Szajewska; Maciej Kołodziej; Dorota Gieruszczak-Białek; Agata Skórka; Marek Ruszczyński; Raanan Shamir


Aliment Pharmacol Ther. 2019;49(11):1376-1384. 

In This Article

Conclusions and Future Research

Despite a recent, large RCT demonstrating no effect of L rhamnosus GG supplementation on acute gastroenteritis, current evidence shows that, overall, L rhamnosus GG reduced the durations of diarrhoea and hospitalisation of inpatients. These findings should be viewed in the context of the high heterogeneity and methodological limitations of the included trials. Nevertheless, these findings indicate that results of a recent, well-conducted RCT may not be sufficient to eliminate L rhamnosus GG from the treatment of children with acute gastroenteritis, at least in the European setting. The findings of this review may inform guideline development groups about the efficacy of L rhamnosus GG for treating children with acute gastroenteritis.