Clinically Relevant Drug-Drug Interactions in Primary Care

Mary Carpenter, PharmD; Holly Berry, PharmD; Allen L. Pelletier, MD


Am Fam Physician. 2019;99(9):558-564. 

In This Article

Clonidine and Beta Blockers

Several reports describe an increased hypertensive response to the withdrawal of clonidine when a beta blocker is being used.[39] In the presence of a beta2-receptor blockade, the vasoconstrictor properties of the catecholamines are unopposed, resulting in the exaggerated hypertensive response within 24 to 72 hours after discontinuation of clonidine.[39] Beta blockers should be tapered and discontinued several days before clonidine withdrawal to reduce the risk of rebound hypertension. Recommendations call for decreasing the dosage of clonidine over several days before discontinuation.[40]