New Findings, Pathophysiology, and Antigen Analysis in Pollen-Food Allergy Syndrome

Akiko Yagami; Motohiro Ebisawa


Curr Opin Allergy Clin Immunol. 2019;19(3):218-223. 

In This Article


Profilins are ubiquitous proteins in all eukaryotic cells.[33] Profilin is a highly conserved 12-to-15-kDa protein that shows great homology throughout different plants, and is one of the main causes of cross-sensitization between pollen and plant-derived foods and is considered a clinically relevant food allergen. Most famous profilins are Bet v 2 (birch) and Phl p 12 (timothy grass).[34] In birch pollen-sensitized individuals, 10–38% are also sensitized to Bet v 2, whereas 14–24% of patients sensitized to the major grass pollen allergen Phl p 1/5 are sensitized to Phl p 12.[35] Profilin has low enzyme and thermal stability,[36] and is therefore, regarded as a mild or incomplete food allergens that can only induce local symptoms.